Wednesday, November 2, 2016

The glorious truth behind the coffee-“I have to poop” meme

There’s a meme circulating on Facebook featuring a coffee cup with top-to-bottom writing as follows: “Ssshhh…almost…now you may speak…nevermind I have to go poop now.” For many people with morning coffee rituals, this about sums it up. You wake up groggy, get a cup of coffee and slowly come to life. And because coffee significantly increases intestinal contractions, due partly to theophylline, a well-known fat-burner, it often facilitates the morning de-bulking ritual often referred to as “taking a poop.”

Less diabetes and colon cancer
Intestinal cleansing is one of the benefits of coffee, along with another related benefit---decreasing glucose absorption, which contributes to coffee drinkers’ decreased risk of developing diabetes. According to a study conducted at the Harvard School of Public Health, drinking one cup of coffee per day decreases the risk of diabetes by 13%, while a four-cup-per-day habit literally cuts the risk in half.

And then there’s the positive effect of coffee on the risk of developing colon cancer. Last spring, results of a study conducted by Stephen Gruber, MD, PhD, MPH, director of the USC Norris Comprehensive Cancer Center, confirmed what other researchers had already established. Coffee decreases the risk of colon cancer in a dose-dependent manner. With more than 9,000 people in the study, Gruber and his colleagues determined that drinking one or two cups of coffee per day decreases the risk of colon cancer by 26%, while drinking upwards of 2.5 cups increases that risk reduction---once again cutting the risk in half.

Another plus: Gruber’s findings are coffee-agnostic. It doesn’t matter if the coffee is decaffeinated or caffeinated; flavored or basic; French, Sumatran, Italian or any other origin. The results are the same. It’s the antioxidants, mainly the polyphenols, that confer this healthy benefit.

What to do about coffee’s negative effects 
So these are all good things---easy pooping, less cancer, the freedom to eat more sweets and dodge the diabetes bullet and coffee’s perk-up effect---are great. But like everything else, there are downsides to drinking coffee.

For people with gallbladder problems, such as gallstones, coffee can be problematic because it causes gallbladder contraction. Major risk factors for gallstones include obesity, cirrhosis or taking anti-cholesterol medications or hormone replacement therapy. Until these problems are resolved, most people with serious gallstones are directed by their physicians to not drink coffee.

In addition, people with ulcers or functional dyspepsia often avoid coffee because of its acid-producing component. However, not all coffees have the same physiological effects. In 2010, Veronika Somoza, Ph.D. from the University of Vienna in Austria, and Thomas Hofmann, Ph.D., from the Technische Universität Műnchen in Germany, presented their findings to the scientific community showing that dark coffee can actually be used to decrease acid production. 
Dr. Veronika Somoza

Dark coffee is easier on the stomach
That’s because dark coffees, such as French roast and espresso, contain more of the key ingredient N-methylpyridium (NMP). NMP is a byproduct of any coffee-roasting process, and in fact only becomes available when coffee beans are roasted. It seems counter-intuitive, but darker roast coffees are easier on the stomach than mild roasts----which also have more caffeine.

What this means is that the 40 million Americans who are currently avoiding coffee because of stomach-related problems can reconsider their dilemma and find a dark coffee brew that works for them. Bu the bottom line is that not everyone can drink coffee. If you can, be grateful---there are a lot of benefits to be had, and the ‘poop factor’ is a scientifically based reality.

Wednesday, October 26, 2016

Using coffee to combat SAD or why pumpkin lattes can make us happier in November

Who doesn’t love the fall? What’s not to love when turning leaves are providing a visual feast of saturated reds and yellows, and it’s absolutely fine to eat an apple cider donut once in a while? People put on their hiking boots, call in the chimney sweep and embrace the culture of harvest in all of its pumpkin-and-hayrides glory.

But there’s a downside for people who suffer from seasonal affective disorder (SAD). As the days get shorter, the lack of sunlight wreaks havoc on their serotonin and melatonin neurotransmitters. Roughly 6% of Americans suffer from SAD and another 14% experience the ‘winter blues,’ a less severe variant of SAD, but very real nonetheless.  

Seventy million Americans face a seasonal problem that wasn’t acknowledged as a real condition until 1984 when Dr. Norman Rosenthal, a clinical psychiatry professor at Georgetown, laid out the diagnostic criteria for SAD.  The DSM-V categorizes SAD as a modifier—“with seasonal pattern” to recurrent major depressive disorder. Common treatments include phototherapy, antidepressants and melatonin supplements. 

Wellbutrin X—the only FDA-approved treatment for SAD
The only FDA-approved treatment for SAD is Wellbutrin XL (bupropion), which was first marketed by GlaxoSmithKline in 1985 and is now available as a generic.  In placebo-controlled studies, patients who had been diagnosed with SAD were started on treatment between September and November. At the end of treatment in late March, 84% of patients were depression-free---an important outcome because one of the major concerns around SAD is that it will escalate into a major depressive episode.

Full Prescribing Information from the Food and Drug Administration is available here

Because SAD usually occurs at the same time each year, starting in mid-to-late fall and ending in spring, it makes sense to anticipate it. Best to deal with SAD early in the fall, because one day you will wake up and realize that the sun will be setting at 4 PM, and all you really want to do is stockpile cookies and rev up the Netflix.

Data: The coffee-depression connection
I’ve reported several times on the link between drinking coffee and decreased depression. Ten-year data from the Nurses’ Health Study showed that drinking 2 to 3 cups of coffee a day decreased the risk of depression by 15%, and a fourth cup led to even better outcomes. Another study with more than 86,000 women showed that drinking 2 to 3 cups of coffee per day decreased the risk of suicide by two-thirds.

However, it really doesn’t take 3 cups of coffee a day to help you feel better. According to a study published in the Proceedings of the National Academy ofMedicine in 2015, the amount of caffeine found in one cup of coffee can improve mood, decrease sleepiness, improve memory and make it easier to deal with stress. 

Coffee as stress reliever
The takeaway: Just grabbing a cup of coffee can help combat the onset of moodiness for people with SAD. I am not suggesting that coffee is a replacement for pharmacologic support---that’s something best dealt with by a medical doctor. However, all evidence points to coffee’s utility as a mood booster and as a way to combat stress.  

Caffeine has a well-known mechanism of action: By blocking adenosine receptors, it short-circuits the body’s sleep-activation mechanism. The same MOA is responsible for improving mood and memory, while also making it easier to handle stress---the bogeyman that can ruin lives. Coffee stops the body’s natural deterioration mechanisms from kicking in.

I drink coffee because I like it and I know it’s good for me, but around this time of year, my coffee-drinking becomes more intentionally utilitarian. I like pumpkins and little goblins, and doing leaf-decoupage projects with my kindergartener. But I hate getting the blues and it happens almost every year. This year, however, I’m ready. Drink up!

Monday, October 17, 2016

A fresh perspective on a five-year-old indie coffee house or why Java Love is still the bomb---By Megan Wilt

Life as a mom in Suburbia can be a bit cookie-cutter.  Life as a stay-at-home-mom in Suburbia can be nearly surreal in its fulfilled expectation.  This is not the 1950s and it’s the rare SAHM who prides herself on a Donna Reed-esque tidy home and nightly roast.  We are modern women living out vintage lives in a modern world. 

Thankfully, for those of us living in the Manhattan-adjacent burbs, there are a few more opportunities that keep us tied to the real world.  It is just a situation like this that draws me to our town’s stand-in for the water cooler – Java Love.  While I have often spent an afternoon sitting in the reclaimed comfort of burlap coffee sacks and beautifully collaged wood, the café thrives as a setting for an afternoon of shop-talk--- getting acquainted with a local friend in a way our busy lives and Facebook banter cannot provide. 

Unlike the ubiquitously-branded Starbucks and Dunkin Donuts stores scattered about town, Java Love tends thankfully toward the adult – no middle schoolers flooding the space with too-large backpacks and too-small manners while on a Pokemon quest.  Nor is Java Love the harbinger of one-size-fits-all milky lattes or burnt-tasting espresso.  Java Love is a real coffee house.  They pride themselves on all things local and roast their own beans. 

Java Love’s offerings are like the old wedding day superstition – something old, something new, something borrowed, something…well, nothing blue, but 3 out of 4 is all you need.  The demand for something old is represented by the reliably consistent quality of your basic espresso drinks.  Java Love has staff that understands the difference between a latte and a macchiato (hint: if you’ve been getting either at Starbucks, you will be surprised by the real thing).  The espresso is always bold and well-rounded and never, ever tastes burnt. 

The “something new” is brought to the customer by the imaginations of the young, hipster-esque staff with seasonal menus and carefully-considered recommendations.  They love to add a unique twist, such as a dash of cayenne powder, squirt of lavender or rose syrup, or using the flavor of almond milk to enhance a nutmeg- and ginger-spiced drink. 

All that said, the shop knows that there will always be someone stopping in for drinks made popular by the big chains, so they’ve also developed some borrowed concepts, like the ever-present pumpkin spice latte (or PSL, if you’re basic).  Admittedly, I tend toward the “something old” side when drinking espresso.  I like my coffee strong and simple.

While the child-free coffee shops are ideal, let’s be honest – the majority of us are in the burbs because we have kids.  Although Java Love is not popular with the roaming tweens and teens, families are welcome.  When Java opened its second location on Church St last spring, I found my children rejoicing right along with me.  We are no longer forced to visit Starbucks after dance class at Sharron Miller’s dance school or trips to the library. 

My 8 year-old daughter is a bit of a Java Love connoisseur, typically choosing a decaf espresso drink while working her way through the flavored syrup choices.  The baristas make sure her drink is never too hot.  My 5 year-old son, on the other hand, chooses between hot chocolate and the regionally-produced apple juice varieties stocked in the cooler.  Our suburban experience would be lacking something essential without Java Love around to provide a welcoming respite.  It feels much like the comfort of your own home, but coffee-stocked and mess-free and, therefore, much more enjoyable. 

Monday, October 10, 2016

Montclair welcomes the crazy dancing goat to the fold

Three weeks ago, there was a pleasant buzz about the latest coffee shop to open in town. Crazy Mocha, located at 491 Bloomfield Avenue on the ground floor of a 93-year-old bank building, is a Pittsburgh-based chain owned by Ken Zeff.

According to a brief convo with the super-friendly, attractive young baristas, Zeff’s brother lives in Montclair. Having spent a fair amount of time visiting his brother, Zeff decided that Montclair would be a good location for another Crazy Mocha storefront.

Because of its philosophy of locating its stores so as not to cannibalize the business of independent coffee shops (such as Java Love downtown on Church St.), its location on Bloomfield Ave. several blocks north of Trend Coffeehouse, is perfect.

Not only is there plenty of table seating, but there is a lounge communal area near the front windows replete with comfortable large leather shares, tables made for hanging out and other little seating nooks for those who are seeking a more relaxed experience. The wifi is reliable.

So how do you turn an almost 100-year-old bank building into a cozy café? It’s called adaptive reuse---a program that allows historic, unused buildings to be repurposed for contemporary uses. Were it not for the interior brick walls (original) and ornate fixtures, such as a large fireplace near the entrance, as well as other interior design features that ground the space, the high ceilings and large windows, might make a person feel that they are in a vault (the building was previously called Vault491). There is even a deposit slot in the door.

Fortunately, all of those architectural features have been leveraged in the interest of creating a nice coffee shop, while retaining the old Italian Renaissance charm of the original building.

The coffee itself is good—hot and well-priced. I had a latte and it delivered---smooth, bold and sufficiently caffeinated. On the food side, Crazy Mocha has the best selection of biscotti that I have ever seen. Sure, you can get plain, chocolate and hazelnut at Crazy Mocha (and everyplace else), but you can also get salted caramel biscotti, apricot-vanilla biscotti and mocha biscotti---with many other biscotti options available.

Traditionally, the chances that a new eatery or restaurant will make it in Montclair have not been encouraging. In fact, Mountie’s Eatery (which I recently reviewed) has already closed, less than three months after opening. I am sad to see it go. However, when it comes to cafés, the town’s appetite for coffee houses and cafés is strong enough to keep all of these places afloat. Welcome to town, Crazy Mocha. 

Tuesday, September 20, 2016

Why craft fair coffee doesn't have to be amazing, it just has to be hot---and available

It’s fall and in fall, people like to get crafty. Craft fairs are a standard-bearer of community tradition, in communities across the world---and coffee is the lubricant that keeps people shopping, buzzing around and having a chance to interact with others.

Just because something is expensive or ‘gourmet’ or deemed ‘high-end’ doesn’t mean it’s good---and even if it is good, sometimes it’s just not necessary. Sometimes all you want and need is a good cup of steeping hot brew and access to whatever it is you like to add to it (milk, sugar, etc.)

 Such was the attitude at the Anderson Park Craft Fair in Montclair, NJ last Sunday. The coffee was provided by CTX Jorges ICE Xpress, LLC, a national food vendor.  It was served by George, who greeted everyone with a smile.

People would breathlessly approach him and say, “Are you the one with the coffee?” He would nod, point them to the Styrofoam cups and let them get a nice cup of coffee for $2.00. Then they would meander over to the funnel cakes, or the hot dogs, or the crafts themselves----lots of amazing art, ranging from wall art, to ceramics, to sculpture and more; beautiful fall-friendly bespoke clothing; all manner of jewelry; gummy bears and worms and more, more, more.

This INFINITY HOOD SCARFWRAP is handmade by Diane, who is the owner of Clozs, along with her husband Eddie. They have every pattern and material imaginable, as well as a choice of lengths and styles. The price-points are very reasonable. Learn more here: 

The reality is that anyone who wanted to walk a block out of the park could have gotten a nice latte from Java Love, or they could have walked three blocks to Starbucks, or two to Dunkin’ Donuts. The point wasn’t the name on the cup. The point was that the coffee was very hot, it was decent, it was caffeinated and it was served with a smile.

Studies have shown that coffee increases social interaction in a positive way. Coffee not only stimulates the brain to neutralize sleepiness, but it also stokes virtually every reward system in the brain, with a huge dollop of dopamine-stimulating affects.

Nothing’s better for business than happy people looking to brighten their lives with beautiful stuff made by people who have dedicated their lives to creating beauty. Those people need coffee too---and deserve a hot cup wherever they go. 

Friday, September 16, 2016

The Second Annual NY Coffee Festival: Coffee, food, fun and a reality check about water

"Water ,water everywhere and not a drop to drink."---From the Rime of the Ancient Mariner by Samuel Coleridge Taylor

The global coffee industry is worth more than $100 billion. So it’s no surprise that there is a full line-up of industry trade shows and conventions scheduled over the next few months in the U.S. Brazil, Hungary, Turkey, China, Switzerland, Colombia, Mexico and the United Arab Emirates.

However, although there are a lot of trade shows for folks involved in the coffee industry, such as growers and coffee farm owners, sometimes the role of the consumer is underappreciated.
Not so with the NY Coffee Festival, which starts today and runs through Sunday late afternoon at NYC’s 69th Regent Amory, located at 68 Lexington Ave. (between 25th and 26th St).

This year’s festival---the second ever---promises to be stimulating, with over 70 coffee, food and equipment suppliers, interactive workshops, barista demonstrations and competitions, lots of nosh, a DJ, bands, art and even coffee cocktails---all for the price of $20 for a standard ticket and $45 for VIP entrance.

Although this is only the festival’s second year, the event will be packed. Last year, there were 12,000 people and given the current buzz, at least 15,000 people are showing up this year.

But here’s the catch. Fifty percent of the proceeds from this event are going to charity: water, a non-profit organization that provides clean and safe drinking water for people in developing nations---including many of those in coffee-producing locales. 

This NYC-based charity is 10 years old, with a history of major success helping people get potable water. Since 2006, the organization has helped fund almost 20,000 projects in 24 countries, benefiting over 6.1 million people and raising more than $200 million.

Watch this video to learn more about the founder,  Scott Harrison, who was previously a beer-guzzling, drug-addled, party-boy nightclub promoter before deciding that his life’s primary mission would be to help the 663 million people in the world who don’t have access to clean or safe water.

Many people die from drinking water infested by bacteria, leading to various tropical diseases and ultimately death, especially for children. Scott decided that he could not stand the thought of a child having to drink scummy water, or lose a day of education to carry that water from far-flung sources. 

He has since planned and executed numerous programs involving digging rigs, freshwater wells and community education.

As you sip coffee this weekend at the NY Coffee Festival, remember that good coffee requires good water to make it safe and drinkable---and also keep in mind the people who are grateful simply to have clean water every day to make way for a better future.

Thursday, September 8, 2016

Pharma’s quest to unlock the molecular mystery of coffee

It’s fascinating to consider how coffee is de-caffeinated. The general idea is that the coffee beans are steamed and then rinsed repeatedly with a solvent to extract the caffeine, while leaving the other components intact.

What happens to the caffeine? It turns out that when coffee companies extract caffeine from coffee beans, they send the caffeine to pharmaceutical companies. Pharma companies then take the caffeine and use it as part of analgesic medications, such as Excedrin and other OTC medications.

The magic of caffeine
Coffee contains lots of things besides caffeine, which is just one of the hundreds of bioactive ingredients found in coffee, in addition to antioxidants, chlorogenic acids, melonoidins and other components.

All of the components of coffee combined confer numerous benefits to those who consume it, such as a decreased risk of diabetes, Parkinson’s disease, certain types of cancer and depression, among other things. However, as the world’s most consumed psychostimulant in the world, coffee owes its astounding popularity to its caffeine.

Targeted adenosine activity
In terms of its mode of action, also known as MOA, coffee is a nonselective antagonist of several adenosine receptors—A1, A2, A2b and A3---meaning it blocks the activity of these receptors, resulting in specific reactions in the central nervous system and the cardiovascular system.

Caffeine’s MOA is compelling because of its immediate and obvious benefits---increased energy and alertness and the ability to perform almost any activity, whether it’s productive or not, better. It all comes down to adenosine blockade.

Harnessing adenosine without side effects
For more than 20 years, pharma companies have been researching potential therapeutic applications of selective adenosine modulation (both blocking and enhancing various adenosine receptors). Researchers have found that effectively manipulating adenosine receptors could help treat the molecular damage and inflammation associated with Alzheimer’s disease, Parkinson’s disease and spinal cord injury.

However, developing effective targeted adenosine modulator therapies has been challenging, because of the ubiquity of adenosine receptors and the problem of side effects. The goal is to not only identify druggable adenosine targets, but  to develop a drug that hits that target without systemic side effects. In fact, there is only one FDA-approved selective adenosine agonist---Lexiscan (regadenison), which is marketed by Astellas.

The first and only adenosine agonist 
Lexiscan is approved for use in cardiac stress imaging in patients who are unable to use a treadmill or stationary bike. For those patients, IV infusion of Lexiscan increases blood flow to the heart for diagnostic purposes.

Companies with adenosine-related products
Three companies---Astellas, Fujisawa and Bedford Labs, manufacture a pure adenosine injection, which is used clinically to help normalize certain abnormal heart rhythms. Meanwhile, Adenosine Therapeutics has been at the forefront of adenosine therapeutic research, with mixed results. The company has been in business since 1999 and has struggled financially, continuing to look for financing or a partner to help it bring its phase 3 cardiac stress agent, Stedivase, to market.

At the moment, coffee remains the most reliable way to manipulate adenosine receptors and achieve physical and psychological (not to mention) social benefits. Drink up.